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Detecting gene-environment interactions using a case-control design

✍ Scribed by Alisa M. Goldstein; Roni T. Falk; Jeannette F. Korczak; Jay H. Lubin

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
61 KB
Volume
14
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

We assessed the sample size required for detecting gene-environment (G × E) interactions in a case-control study of complex diseases. The results suggest that large numbers of cases and controls will be required to detect G × E interaction for some odds ratio and exposure frequency combinations. These and other results suggest that alternative study designs may be needed to detect G × E interaction particularly with rare genes or uncommon environmental exposures.

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