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Detailed studies on the enantioselective synthesis and HPLC enantioseparation of N-protected 3-hydroxyglutarimides

✍ Scribed by Yuan-Ping Ruan; Bang-Guo Wei; Xiu-Qing Xu; Gang Liu; De-Sheng Yu; Liang-Xian Liu; Pei-Qiang Huang

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
127 KB
Volume
17
Category
Article
ISSN
0899-0042

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✦ Synopsis

Abstract

An analytical HPLC method using CHIREX (S)‐LEU/(S)‐α‐NEA column was developed for the determination of the enantiomeric excesses of N‐protected (S)‐3‐hydroxyglutarimides. Using this method, detailed studies on the base‐promoted ring‐expansion reaction of the amidolactones, derived from l‐glutamic acid, were undertaken. © 2005 Wiley‐Liss, Inc. Chirality 17:595–599, 2005.

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