## Abstract The frequent presence of loss of heterozygosity (LOH) at 21q21 in lung cancer suggests the existence of putative tumor suppressor genes in this genomic region. Furthermore, the identification of a homozygous deletion in this region has lent further support for its potential involvement
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Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer
β Scribed by Konishi, Hiroyuki; Sugiyama, Miyabi; Mizuno, Kotaro; Saito, Hiroko; Yatabe, Yasushi; Takahashi, Toshitada; Osada, Hirotaka; Takahashi, Takashi
- Book ID
- 110067419
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 695 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract We have previously shown that inoculation of human chromosome 3 (chr3)/A9 mouse fibrosarcoma microcell hybrids (MCHs) into severely combined immunodeficient (SCID) mice was followed by the regular elimination of certain 3p regions, whereas a 3q region was retained even after prolonged m