Desulfurization of 2-Thioxo-1,2,3,4-tetrahydropyrimidin-4-ones with Oxiranes and 2-Haloacetonitriles
β Scribed by I. A. Novakov; B. S. Orlinson; M. B. Navrotskii
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2005
- Tongue
- English
- Weight
- 57 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1070-4280
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π SIMILAR VOLUMES
Alkylation of 1-(3,4-Disubstituted Phenyl)-2-thioxo-1,2,5,6tetrahydropyrimidin-4(3H)-ones. -Alkylation of the title compounds (I), (VI), and (IX) results in the formation of S-and N-methylated derivatives. S-methylated products (III), (VII), and (X) are always the major products. In all cases, meth
In the crystal structure of the title compound, C 16 H 17 N 5 O 2 S, molecules are linked by two N-HΓ Γ ΓS hydrogen bonds, with N-S distances of 3.3469 (13) and 3.3703 (13) A Λand N-H Γ Γ ΓS angles of 158 and 162 .
In the title compound, C 15 H 18 N 2 O 4 S, the packing is consolidated by an intra/intermolecular bifurcated O-HΓ Γ Γ(O,O) and intermolecular N-HΓ Γ ΓS hydrogen bonds. The tetrahydropyrimidin-2-one ring is twisted. ## Related literature For background, see: Kappe (1993). ## Experimental Cryst
The title compound, C 14 H 16 N 2 O 4 S, was synthesized by the reaction of 4-hydroxy-3-methoxybenzaldehyde, thiourea and methyl 3-oxobutanoate in ethanol under reflux. The crystal structure is stabilized mainly through intermolecular N-HΓ Γ ΓS and O-HΓ Γ ΓO hydrogen bonds. The tetrahydropyrimidin-2