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Destruction of norepinephrine terminals in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice reduces locomotor activity induced by l-DOPA

✍ Scribed by Nishi, Katsunori; Kondo, Tomoyoshi; Narabayashi, Hirotaro


Book ID
122753942
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
349 KB
Volume
123
Category
Article
ISSN
0304-3940

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP