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Depletion of cardiac norepinephrine in rats and mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

✍ Scribed by Ray W. Fuller; Richard A. Hahn; Harold D. Snoddy; James H. Wikel


Book ID
115777815
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
323 KB
Volume
33
Category
Article
ISSN
0006-2952

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP