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Acute ultrastructural and behavioral effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice

✍ Scribed by Linder, Jean C.; Klemfuss, Harry; Groves, Philip M.


Book ID
123228309
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
677 KB
Volume
82
Category
Article
ISSN
0304-3940

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP