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Acute and Long Term Effects of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) in Tests of Nociception in Mice

✍ Scribed by Rosland, Jan Henrik ;Hunskaar, Steinar ;Broch, Ole Jacob ;Hole, Kjell


Book ID
114801733
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
725 KB
Volume
70
Category
Article
ISSN
0901-9928

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP