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Desipramine-induced Ca2+ movement and cytotoxicity in PC3 human prostate cancer cells

✍ Scribed by Chun-Jen Huang; He-Hsiung Cheng; Chiang-Ting Chou; Chun-Chi Kuo; Yih-Chau Lu; Li-Ling Tseng; Sau-Tung Chu; Shu-Shong Hsu; Jue-Long Wang; Ko-Long Lin; I-Shu Chen; Shiuh-Inn Liu; Chung-Ren Jan

Book ID
116919549
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
249 KB
Volume
21
Category
Article
ISSN
0887-2333

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## Abstract The present study evaluated the effects of thimerosal, a vaccine preservative, on cytosolic free Ca^2+^ concentrations ([Ca^2+^]~i~) in human prostate cancer cells (PC3). Thimerosal (10–200 ¡M) increased [Ca^2+^]~i~ in a concentration‐dependent manner. The Ca^2+^ signal was reduced part