✦ LIBER ✦

DESIGNING STUDIES FOR DOSE RESPONSE

✍ Scribed by WENG KEE WONG; PETER A. LACHENBRUCH

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 967 KB
Volume: 15
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19960229)15:4<343::aid-sim163>3.0.co;2-f

No coin nor oath required. For personal study only.

✦ Synopsis

Dose response' refers to the regression of a response on a stimulus. We review a number of options for doseresponse designs, and compare various designs which may be used in practice. We start with two group designs. Next, we introduce basic optimal approximate design theory for simple linear and quadratic regression illustrating different criteria of optimality and their effect on the allocation of the levels of the dose. Then we obtain the efficiencies of these optimal approximate designs and some simple designs which have intuitive appeal (symmetry, equal spacing of treatments, reduced numbers of observations at the highest and lowest doses).

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