✦ LIBER ✦

Designing focused libraries using MoSELECT

✍ Scribed by Valerie J. Gillet; Peter Willett; Peter J. Fleming; Darren V.S. Green

Book ID: 108488193
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 215 KB
Volume: 20
Category: Article
ISSN: 1093-3263
DOI: 10.1016/s1093-3263(01)00150-4

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## Abstract 1‐Phenyl‐4‐piperazinyl‐carbonyl‐substituted nitrogen‐containing heterocycles were discovered at Zentaris as a new class of potent, synthetic, small molecule tubulin inhibitors with strong antiproliferative activity. The lead structure of this class, **D‐24203**, proved to be a potent in