Design and Synthesis of a Focused Librar
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Matthias Gerlach; Eckhard Claus; Silke Baasner; Gilbert Müller; Emmanuel Polymer
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Article
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2004
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John Wiley and Sons
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English
⚖ 145 KB
👁 2 views
## Abstract 1‐Phenyl‐4‐piperazinyl‐carbonyl‐substituted nitrogen‐containing heterocycles were discovered at Zentaris as a new class of potent, synthetic, small molecule tubulin inhibitors with strong antiproliferative activity. The lead structure of this class, **D‐24203**, proved to be a potent in