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Design, Synthesis and Structure−Activity Relationships of Novel Taxane-Based Multidrug Resistance Reversal Agents

✍ Scribed by Ojima, Iwao; Borella, Christopher P.; Wu, Xinyuan; Bounaud, Pierre-Yves; Oderda, Cecilia Fumero; Sturm, Matthew; Miller, Michael L.; Chakravarty, Subrata; Chen, Jin; Huang, Qing


Book ID
115501978
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
422 KB
Volume
48
Category
Article
ISSN
0022-2623

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Two types of sinenxan A derivatives with different side chains at C-5 were synthesized and evaluated for their in vitro multidrug resistant reversal activities. Several derivatives exhibited better activities than the positive control verapamil. The structure-activity relationships of these derivati