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Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

โœ Scribed by Wang, Gary T.; Chen, Yuanwei; Wang, Sheldon; Gentles, Robert; Sowin, Thomas; Kati, Warren; Muchmore, Steve; Giranda, Vincent; Stewart, Kent; Sham, Hing; Kempf, Dale; Laver, W. Graeme


Book ID
125543890
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
457 KB
Volume
44
Category
Article
ISSN
0022-2623

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Polyaniline supported cobalt(II) salen c
โœ T. Punniyamurthy; Javed Iqbal ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 178 KB

A novel synthesis of pyrrolidine containing tx-hydroxyamide core structures as inhibitors for HIV protease is developed by employing polyaniline supported cobalt (II) salen catalysed formation of the epoxide from cinnamoylamides of L-proline followed by its opening with anilines at ambient condition