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Design, Synthesis, and SAR of 2-Dialkylamino-4-arylpyrimidines as Potent and Selective Corticotropin-Releasing Factor1 (CRF1) Receptor Antagonists.

✍ Scribed by Charles Q. Huang; Dimitri E. Grigoriadis; Zhengyu Liu; James R. McCarthy; John Ramphal; Thomas Webb; Jeffrey P. Whitten; Michael Y. Xie; Chen Chen


Publisher
John Wiley and Sons
Year
2004
Weight
62 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Two new classes of potent and selective CRF~1~ receptor antagonists are presented. Exploration of general templates **3** and **4** through modifications of the top amine and bottom phenyl substituents led to optimization of the inβ€…vitro affinity and pharmacokinetic profiles. The typica