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Design, Synthesis, and Pharmacological Investigation of Iodined Salicylimines, New Prototypes of Antimicrobial Drug Candidates

✍ Scribed by Suo-Ping Xu; Peng-Cheng Lv; Lei Shi; Hai-Liang Zhu

Book ID
102749599
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
708 KB
Volume
343
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

A series of 3,5‐diiodo‐salicylalidene Schiff bases (compounds 1–35) has been synthesized and tested for antimicrobial activity. The compounds were assayed for antibacterial activities by the MTT method. Some of the compounds inhibit the growth of a broad range of bacteria including the species of Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter cloacae. Among them, compounds 2‐[(4‐chloro‐phenylimino)methyl]‐4,6‐diiodo‐phenol 11 and 2,4‐diiodo‐6‐[(2‐morpholin‐4‐yl‐ethylimino)methyl]phenol 19 showed the most potent antibacterial activity with MIC of 3.1, 12.9, 3.3, 6.5, 12.9, 3.3 and 3.2, 12.8, 3.2, 12.8, 12.8, 3.2 μM against B. subtilis, S. aureus, S. faecalis, P. aeruginosa, E. Coli, and E. cloacae, respectively.

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