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Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors

✍ Scribed by Lianbao Ye; Yuanxin Tian; Zhonghuang Li; Hong Jin; Zhengguang Zhu; Shanhe Wan; Junyan Zhang; Pengjiu Yu; Jiajie Zhang; Shuguang Wu


Book ID
113583321
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
541 KB
Volume
50
Category
Article
ISSN
0223-5234

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## Abstract Since deregulation of the tyrosine‐kinase receptor c‐Met is implicated in several human cancers and is an attractive target for small‐molecule‐drug discovery, we report herein the synthesis of 2,3,4,5‐tetrahydro‐8‐[1‐(quinolin‐6‐ylmethyl)‐1__H__‐1,2,3‐triazolo[4,5‐__b__]pyrazin‐6‐yl]‐1_