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Design, Synthesis, and Initial Evaluation of High-Affinity Technetium Bombesin Analogues

✍ Scribed by Baidoo, Kwamena E.; Lin, Kuo-Shyan; Zhan, Yougen; Finley, Paige; Scheffel, Ursula; Wagner, Henry N.

Book ID
127190196
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
122 KB
Volume
9
Category
Article
ISSN
1043-1802

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Synthesis and biological evaluation of C
Synthesis and biological evaluation of C-terminal hydroxamide analogues of bombesin
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Bombesin pseudo-peptide analogues containing a hydroxamide function on the C-terminal part of the molecule, e.g. H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOBzl 1 and H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOH 2 were synthesized. These compounds were tested for their ability to recognize the bombesin recep