Design, Synthesis, and Biological Evaluation of an Antagonist−Bombesin Analogue as Targeting Vector
✍ Scribed by Abd-Elgaliel, Wael R.; Gallazzi, Fabio; Garrison, Jered C.; Rold, Tammy L.; Sieckman, Gary L.; Figueroa, Said Daibes; Hoffman, Timothy J.; Lever, Susan Z.
- Book ID
- 126254603
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 472 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1043-1802
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📜 SIMILAR VOLUMES
Bombesin pseudo-peptide analogues containing a hydroxamide function on the C-terminal part of the molecule, e.g. H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOBzl 1 and H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOH 2 were synthesized. These compounds were tested for their ability to recognize the bombesin recep
## Abstract Five novel compounds composed of etoposide and 5‐fluorouracil derivatives joined by an ester linkage were prepared and evaluated for their antitumor potential. Most of these analogues have exhibited promising __in vitro__ cytotoxic activity against cell cultures of murine leukaemia P‐38