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Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone

✍ Scribed by Antti Mäntylä; Jarkko Rautio; Tapio Nevalainen; Pekka Keski-Rahkonen; Jouko Vepsälainen; Tomi Järvinen

Book ID: 113591372
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 129 KB
Volume: 23
Category: Article
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2004.06.006

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## Abstract Silybin, the main component of silymarin, is an antihepatotoxic agent. But it presents numerous challenges associated with its poor aqueous solubility which has been realized as the major problem in its dosage form development and clinical application. The objective of our study was to