𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vitro and in vivo evaluation of a novel water-soluble N-glycyl prodrug (N-GLY-CBZ) of carbamazepine

✍ Scribed by Jeffrey N. Hemenway; Valentino J. Stella

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
231 KB
Volume
99
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Preparation and physicochemical characte
Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine
✍ Jeffrey N. Hemenway; Pekka Jarho; John T. Henri; Sajiv K. Nair; David VanderVeld πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 229 KB

N-acyl-urea derivatives of carbamazepine (CBZ) were synthesized through the reactions of iminostilbene with acyl-isocyanates to form N-glycyl-carbamazepine (N-Gly-CBZ, after a deprotection step) or N-acetyl-carbamazepine (N-acetyl-CBZ). N-Gly-CBZ was isolated as its water-soluble HCl salt and was de

Use of in vitro lipid digestion data to
Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: Studies with halofantrine
✍ Christopher J.H. Porter; Ann Marie Kaukonen; Agnes Taillardat-Bertschinger; Ben πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 196 KB πŸ‘ 1 views

The relative oral bioavailability (BA) of halofantrine base (Hf) was assessed in male beagle dogs after administration of a medium chain triglyceride (MCT), a long chain triglyceride (LCT), and a blended LCT/MCT lipid solution formulation of Hf (Study 1) and after administration of suspensions of Hf

Preparation and in vitro evaluation of 9
Preparation and in vitro evaluation of 99mTc-labelled bovine lactadherin as a novel radioligand for apoptosis detection
✍ Lasse N. Waehrens; Jan T. Rasmussen; Christian W. Heegaard; Lise Falborg πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 129 KB

## Abstract Lactadherin is an opsonin, which binds with high affinity to phosphatidylserine exposed on the surface of apoptotic cells via its C1C2 domains. Phagocytosis of the apoptotic cells is then facilitated by an Arg‐Gly‐Asp (RGD)‐ mediated binding to macrophages surface integrins. The present