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Design, synthesis and in vitro activities of a series of benzimidazole/benzoxazole glycoprotein IIb/IIIa inhibitors

✍ Scribed by Chu-Biao Xue; Maria Rafalski; John Roderick; Charles J. Eyermann; Shaker Mousa; Richard E. Olson; William F. DeGrado


Book ID
103983239
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
304 KB
Volume
6
Category
Article
ISSN
0960-894X

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Non-peptide glycoprotein IIb/IIIa inhibi
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Low molecular weight non-peptide inhibitors of platelet aggregation based on rigid bicyclic scaffolds are described. Consideration of the reported conformational preferences of 1-alkyl-3-carbonyl pyrroles led to the synthesis of pyrrolopiperazinone 2a which was shown to be a potent, selective antago