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Design, synthesis and evaluation of two diastereoisomeric phosphonate inhibitors of lamb pregastric lipase

✍ Scribed by Carol M Taylor; Charmian J O’Connor; Jennifer L Chamberlain; Cynthia Q Sun


Book ID
114395638
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
148 KB
Volume
15
Category
Article
ISSN
1381-1177

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Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.