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Design, synthesis and evaluation of new RDP inhibitors

✍ Scribed by Hallur Gurulingappa; Phillip Buckhaults; Srinivas K. Kumar; Kenneth W. Kinzler; Bert Vogelstein; Saeed R. Khan

Book ID
104253022
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
132 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.

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