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Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction

✍ Scribed by Prasanthi, G.; Prasad, K.V.S.R.G.; Bharathi, K.

Book ID: 120441682
Publisher: Elsevier Science
Year: 2013
Tongue: French
Weight: 529 KB
Volume: 66
Category: Article
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2013.06.006

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## Abstract The Hantzsch condensation of 5‐formyluracil (**1**) with methyl, isopropyl or isobutyl acetoacetate **(2a‐c)** in the presence of ammonium hydroxide afforded the respective dialkyl 1,4‐dihydro‐2,6‐dimethyl‐4‐(2,4‐dloxo‐1,2,3,4,‐tetrahydropyrimidin‐5‐yl)pyridine‐3,5‐dicarboxylate **(3a‐c