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Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4′-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate

✍ Scribed by Meral Tunçbilek; Süheyla Özbey; Engin Kendi; Engin Yıldırım; Kevser Erol; Rahmiye Ertan

Book ID
114019530
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
139 KB
Volume
54
Category
Article
ISSN
0014-827X

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We report the synthesis and X-ray crystal structure of 1,4-dihydro-2,6-dimethyl-4-(2'isopropylphenyl)-3,5-pyridine-dicarboxylic acid dimethyl ester (4), an analogue of the 1,4dihydropyridine calcium channel antagonist, nifedipine. Solution state NOE data indicate the presence of both rotameric forms