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Design, Synthesis, and Enzymatic Evaluation of N 1 -Acyloxyalkyl- and N 1 -Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

✍ Scribed by Moreira, Rui; Santana, Ana Bela; Iley, Jim; Neres, João; Douglas, Kenneth T.; Horton, Peter N.; Hursthouse, Michael B.


Book ID
126075689
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
351 KB
Volume
48
Category
Article
ISSN
0022-2623

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## Abstract __N__‐[2‐([1,2,4]Oxadiazol‐5‐yl)cyclopenten‐1‐yl]formamide oximes were synthesized by fusion of (6,7‐dihydro‐5__H__‐cyclopenta[1,2‐__d__]pyrimidin‐4‐yl)amidines and/or their amide oximes with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Assay of the products