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Polycyclic N-heterocyclic compounds. Part 66: Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation

✍ Scribed by Kensuke Okuda; Ying-Xue Zhang; Hiromi Ohtomo; Takashi Hirota; Kenji Sasaki

Book ID: 102343190
Publisher: Journal of Heterocyclic Chemistry
Year: 2011
Tongue: English
Weight: 172 KB
Volume: 48
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.564

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✦ Synopsis

Abstract

N‐[2‐([1,2,4]Oxadiazol‐5‐yl)cyclopenten‐1‐yl]formamide oximes were synthesized by fusion of (6,7‐dihydro‐5__H__‐cyclopenta[1,2‐d]pyrimidin‐4‐yl)amidines and/or their amide oximes with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Assay of the products for anti‐platelet aggregation activity revealed that certain of them showed promising inhibitory effect on arachidonic acid‐induced platelet aggregation. J. Heterocyclic Chem., (2011).

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