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Design, Synthesis, and Biological Evaluation of Phosphinopeptides against Trypanosoma cruzi Targeting Trypanothione Biosynthesis

✍ Scribed by Ravaschino, Esteban L.; Docampo, Roberto; Rodriguez, Juan B.


Book ID
126014400
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
179 KB
Volume
49
Category
Article
ISSN
0022-2623

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Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou