𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design, Synthesis, and Biological Evaluation of New Growth Inhibitors of Trypanosoma cruzi (Epimastigotes)

✍ Scribed by Schvartzapel, Andrea J.; Zhong, Li; Docampo, Roberto; Rodriguez, Juan B.; Gros, Eduardo G.


Book ID
126427760
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
297 KB
Volume
40
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Biological evaluation of two potent inhi
✍ Juan B. Rodriguez; Li Zhong; Roberto Docampo; Eduardo G. Gros πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 219 KB

+)-S-Ethyl- [3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thiolcarbonate (1) and 4phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented high

Design, synthesis, and anti- Trypanosoma
✍ Andrea J. Schvartzapel; Laura Fichera; MΓ³nica Esteva; Juan B. Rodriguez; Eduardo πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 German βš– 563 KB

Several compounds, structurally related to the insect-growth regulator Fenvxycarb (l), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanmvma cruzi cells (epimastigotes). Compounds 6,16, 18, and 22 were very active against 7'. cruzi making them promising good c

Design, Synthesis and Biological Evaluat
✍ Daniel Spinks; Dr. Leah S. Torrie; Dr. Stephen Thompson; Dr. Justin R. Harrison; πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 318 KB πŸ‘ 1 views

Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou