Design, Synthesis, and Biological Evaluation of New Growth Inhibitors of Trypanosoma cruzi (Epimastigotes)
β Scribed by Schvartzapel, Andrea J.; Zhong, Li; Docampo, Roberto; Rodriguez, Juan B.; Gros, Eduardo G.
- Book ID
- 126427760
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 297 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
+)-S-Ethyl- [3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thiolcarbonate (1) and 4phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented high
Several compounds, structurally related to the insect-growth regulator Fenvxycarb (l), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanmvma cruzi cells (epimastigotes). Compounds 6,16, 18, and 22 were very active against 7'. cruzi making them promising good c
Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou