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Design, synthesis and biological evaluation of N-phenylsulfonylnicotinamide derivatives as novel antitumor inhibitors

โœ Scribed by Hui Zhang; Xiang Lu; Li-Rong Zhang; Jia-Jia Liu; Xian-Hui Yang; Xiao-Ming Wang; Hai-Liang Zhu

Book ID
113495677
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
322 KB
Volume
20
Category
Article
ISSN
0968-0896

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Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors
โœ Ying Yang; Lei Shi; Yang Zhou; Huan-Qiu Li; Zhen-Wei Zhu; Hai-Liang Zhu ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 321 KB

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical