Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine

✍ Scribed by Amir P. Tamiz; Miles P. Smith; Alan P. Kozikowski

• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 154 KB
• Volume: 10
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(99)00685-x

✦ Synopsis

The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter.