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Synthesis and Biological Evaluation of C7-Demethyl Largazole Analogues

✍ Scribed by Fei Chen; An-Hui Gao; Jia Li; Fa-Jun Nan


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
436 KB
Volume
4
Category
Article
ISSN
1860-7179

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✦ Synopsis


Largazole (1) is a densely functionalized macrocyclic depsipeptide that was isolated from the cyanobacterium Symploca sp.


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Synthesis and biological evaluation of C
✍ Chantal Devin; Nicole Bernad; MichΓ¨le Cristau; Anne-Marie Artis-Noel; Annie Heit πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 126 KB πŸ‘ 2 views

Bombesin pseudo-peptide analogues containing a hydroxamide function on the C-terminal part of the molecule, e.g. H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOBzl 1 and H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOH 2 were synthesized. These compounds were tested for their ability to recognize the bombesin recep