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Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents

✍ Scribed by Inam, Afreen; Siddiqui, Shadab Miyan; Macedo, Taís Soares; Moreira, Diogo Rodrigo Magalhaes; Leite, Ana Cristina Lima; Soares, Milena Botelho Pereira; Azam, Amir

Book ID: 122130874
Publisher: Elsevier Science
Year: 2014
Tongue: French
Weight: 854 KB
Volume: 75
Category: Article
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2014.01.023

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## Abstract A novel series of 4‐substituted 1‐{[4‐(10,15,20‐triphenylporphyrin‐5‐yl)phenyl]methylidene}thiosemicarbazide, **4a**–**4n**, was synthesized in 9–21% yield by the condensation of 4‐(10,15,20‐triphenylporphyrin‐5‐yl)benzaldehyde (**3**) with various substituted thiosemicarbazides in pres