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Design, synthesis and biological characterization of novel inhibitors of CD38

✍ Scribed by Leung, Fung Ping; Lam, Connie Mo Ching.; Kwong, Anna Ka Yee; Dong, Min; Si, Yuan-Qi; Sun, Shuang-Yong; Pu, Xiao-Ping; Yang, Zhen-Jun; Zhang, Liang-Ren; Zhang, Li-He

Book ID
111901689
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
529 KB
Volume
9
Category
Article
ISSN
1477-0520

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Design, Synthesis and Biological Activit
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✍ Mohamed I. Attia; Meike Timmermann; Petra HΓΆgger; Claus Herdeis πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 151 KB

## Abstract A series of metalloproteinase CD163 ectodomain shedding inhibitors based on azasugar hydroxamic acid scaffold has been synthesized. Among the synthesized compounds, the benzyl derivative **4a** and the methyl derivative **4f** exhibits 66 and 51 % inhibition, respectively, at 1 ΞΌM conce