✦ LIBER ✦

Design, Synthesis and Biological Activity of Azasugar-Based CD163 Ectodomain Shedding Inhibitors

✍ Scribed by Mohamed I. Attia; Meike Timmermann; Petra Högger; Claus Herdeis

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 151 KB
Volume: 2007
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200700178

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✦ Synopsis

Abstract

A series of metalloproteinase CD163 ectodomain shedding inhibitors based on azasugar hydroxamic acid scaffold has been synthesized. Among the synthesized compounds, the benzyl derivative 4a and the methyl derivative 4f exhibits 66 and 51 % inhibition, respectively, at 1 μM concentration on CD163 shedding from human monocytes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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