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Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated α-Linked Acidic Dipeptidase

✍ Scribed by Jackson, Paul F.; Cole, Derek C.; Slusher, Barbara S.; Stetz, Susan L.; Ross, Laurie E.; Donzanti, Bruce A.; Trainor, Diane Amy


Book ID
111875403
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
140 KB
Volume
39
Category
Article
ISSN
0022-2623

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✍ Gante, Joachim ;Krug, Michael ;Lauterbach, Günter ;Weitzel, Reinhard 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB

## Abstract A highly potent renin inhibitor of the azapeptide type (2) is synthesized by starting from the hydrazine derivative 3. This peptide analogue inhibits renin in the same range (nanomolar) as its purely peptidic original 2a, but reveals much higher specificity for renin than 2a does.