Design, Synthesis, and Application of a C 2 Symmetric Chiral Ligand for Enantioselective Conjugate Addition of Organolithium to α,β-Unsaturated Aldimine. -Acyclic aldimines (I), cyclic aldimines (IV), and naphthaldehyde imines like (VI) undergo enantioselective conjugate additions to organolithiums
✦ LIBER ✦
Design, Synthesis, and Application of a C 2 Symmetric Chiral Ligand for Enantioselective Conjugate Addition of Organolithium to α,β-Unsaturated Aldimine
✍ Scribed by Shindo, Mitsuru; Koga, Kenji; Tomioka, Kiyoshi
- Book ID
- 126106584
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 91 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
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Several new chiral auxiliaries with differing steric and electronic environments, such as ␣,␣Ј-dimethyl-2,6-pyridinedimethanol, ␣,␣Ј-ditrifluoromethyl-2,6pyridinedimethanol, ␣,␣Ј-dipentafluoroethyl-2,6-pyridinedimethanol, and ␣,␣Ј-diallyl-2,6pyridinedimethanol, have been examined and compared with ␣