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Design, Properties, and Effective Use of the Oral Chelator L1 and Other : α-Ketohydroxypyridines in the Treatment of Transfusional Iron Overload in Thalassemia

✍ Scribed by GEORGE J. KONTOGHIORGHES


Book ID
119864556
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
648 KB
Volume
612
Category
Article
ISSN
0890-6564

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The prospect of selecting oral a-ketohydroxypyrldine chelators Intended for clinical use in iron overload has been examined using several animal models of efficacy and toxicity. Studies using iron dextran-loaded mice labelled with 50Fe have shown that only the 1-substituted methyl, ethyl, (n)propyl,