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Design of the hapten for the induction of antibodies catalyzing aldol reaction

✍ Scribed by Kazuo Teraishi; Minoru Saito; Ikuo Fujii; Haruki Nakamura

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
349 KB
Volume
12
Category
Article
ISSN
0263-7855

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Design and synthesis of haptens for antibody catalyzed hydrolysis of organophosphorus nerve agents
✍ Pierre-Yves Renard; Philippe Vayron; FrΓ©dΓ©ric Taran; Charles Mioskowski πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 221 KB

Haptens bearing phosphorane and c~-hydroxyphosphinate structures have been designed and synthesized for the selection of monoclonal antibodies with phosphatase like activity in order to detoxify highly toxic organophosphorus chemical weapons such as VX.