Design of peptides: synthesis, crystal structure and molecular conformation of N-Boc-l-Val-ΔPhe-l-Val-OC H3
✍ Scribed by S.N. Mitra; S. Dey; S. Bhatia; T.P. Singh
- Book ID
- 116091673
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 656 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0141-8130
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The peptide BOC-L-Val-APhe-APhe-L-Val-OCH3 was synthesized by the azlactone method in solution phase, and its crystal and molecular structures were determined by x-ray diffraction method. Single crystals were grown by slow evaporation from a methanol/water solution at 6°C. The crystals belong to an
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To obtain general rules of peptide design using alpha, beta-dehydro-residues, a sequence with two consecutive delta Phe-residues, Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3, was synthesized by azlactone method in solution phase. The peptide was crystallized form its solution in an acetone/water mixtur
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