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Design of peptides: synthesis, crystal structure and molecular conformation of N-Boc-l-Val-ΔPhe-l-Val-OC H3

✍ Scribed by S.N. Mitra; S. Dey; S. Bhatia; T.P. Singh


Book ID
116091673
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
656 KB
Volume
19
Category
Article
ISSN
0141-8130

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The peptide BOC-L-Val-APhe-APhe-L-Val-OCH3 was synthesized by the azlactone method in solution phase, and its crystal and molecular structures were determined by x-ray diffraction method. Single crystals were grown by slow evaporation from a methanol/water solution at 6°C. The crystals belong to an

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To obtain general rules of peptide design using alpha, beta-dehydro-residues, a sequence with two consecutive delta Phe-residues, Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3, was synthesized by azlactone method in solution phase. The peptide was crystallized form its solution in an acetone/water mixtur

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Highly specific peptide structures can be designed by inserting dehydro residues into peptide sequences. The peptide N-Boc-L-Phe-dehydro-Phe-L-Val-L-Phe-dehydro-Phe-~-V~-OCH~, synthesized by conventional procedures, crystallizes from methanol-water mixtures at 4°C in the tetragonal space group P43 w

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The peptide N-Boc-L-Phe-dehydro-Leu-L-Val-OCH3 was synthesized by the usual workup procedure and finally by coupling the N-Boc-L-Phe-dehydro-Leu-OH to valine methyl ester. It was crystallized from its solution in methanol-water mi5ture a t 4°C. The crystals belong to the triclinic space group P1 wit