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Design of peptides: synthesis, crystal structure and molecular conformation of N-Boc-L-Val-δPhe-L-Ile-OCH3

✍ Scribed by DEY, SHARMISTHA ;MITRA, SHOME NATH ;SINGH, TEJ. P.


Book ID
115099868
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
474 KB
Volume
48
Category
Article
ISSN
0367-8377

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Design of peptides using α,β-dehydro-res
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The peptide BOC-L-Val-APhe-APhe-L-Val-OCH3 was synthesized by the azlactone method in solution phase, and its crystal and molecular structures were determined by x-ray diffraction method. Single crystals were grown by slow evaporation from a methanol/water solution at 6°C. The crystals belong to an

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To obtain general rules of peptide design using alpha, beta-dehydro-residues, a sequence with two consecutive delta Phe-residues, Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3, was synthesized by azlactone method in solution phase. The peptide was crystallized form its solution in an acetone/water mixtur

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The peptide N-Boc-L-Phe-dehydro-Leu-L-Val-OCH3 was synthesized by the usual workup procedure and finally by coupling the N-Boc-L-Phe-dehydro-Leu-OH to valine methyl ester. It was crystallized from its solution in methanol-water mi5ture a t 4°C. The crystals belong to the triclinic space group P1 wit