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Design of oseltamivir analogs inhibiting neuraminidase of avian influenza virus H5N1

✍ Scribed by Thanyada Rungrotmongkol; Vladimir Frecer; Wanchai De-Eknamkul; Supot Hannongbua; Stanislav Miertus


Book ID
113457904
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
583 KB
Volume
82
Category
Article
ISSN
0166-3542

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Computational studies of H5N1 influenza
✍ Nick X. Wang; Jie J. Zheng πŸ“‚ Article πŸ“… 2009 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 433 KB

## Abstract Influenza A (H5N1) virus is one of the world's greatest pandemic threats. Neuraminidase (NA) inhibitors, oseltamivir and zanamivir, prevent the spread of influenza, but drug‐resistant viruses have reduced their effectiveness. Resistance depends on the binding properties of NA‐drug compl