Molecular dynamics simulation of oseltamivir resistance in neuraminidase of avian influenza H5N1 virus
β Scribed by Mao Shu; Zhihua Lin; Yunru Zhang; Yuqian Wu; Hu Mei; Yongjun Jiang
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 573 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1610-2940
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## Abstract Influenza A (H5N1) virus is one of the world's greatest pandemic threats. Neuraminidase (NA) inhibitors, oseltamivir and zanamivir, prevent the spread of influenza, but drugβresistant viruses have reduced their effectiveness. Resistance depends on the binding properties of NAβdrug compl
Influenza pandemics are recurring events that can potentially lead to millions of human fatalities (Fauci, 2006). Since 1996, lineages of influenza A subtype H5N1 have spread from their origin in China to other regions in Asia, Russia, India, Pakistan, the Middle East, Africa, and Europe (Chen et al