๐”– Bobbio Scriptorium
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Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents

โœ Scribed by Wang, Xiu-Jun; Yang, Ming-Li; Zhang, Lan-Ping; Yao, Tong; Chen, Cheng; Mao, Lian-Gang; Wang, Yin; Wu, Jie


Book ID
123329117
Publisher
Chinese Electronic Periodical Services
Year
2014
Tongue
English
Weight
604 KB
Volume
25
Category
Article
ISSN
1001-8417

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Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that posses cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.