Design of molecular function: Channel proteins - a test case.
β Scribed by M. Montal; A. Grove; T. Iwamoto; M.Oblatt Montal; J. Tomich
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 64 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0162-0134
No coin nor oath required. For personal study only.
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Nanosecond molecular dynamics simulations in a fully solvated phospholipid bilayer have been performed on single transmembrane β£-helices from three putative ion channel proteins encoded by viruses: NB (from influenza B), CM2 (from influenza C), and Vpu (from HIV-1). β£-Helix stability is maintained w
## Abstract Unnatural amino acids are effective as building blocks to design functional peptides from the following two points: (1) utilization of rigid unnatural amino acids for the incorporated peptides to control the conformation to appear the function, and (2) incorporation of functional and un