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Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair

โœ Scribed by Shigeki Sasaki; Shouji Nakashima; Fumi Nagatsugi; Yoshitsugu Tanaka; Masao Hisatome; Minoru Maeda


Book ID
103401943
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
305 KB
Volume
36
Category
Article
ISSN
0040-4039

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We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-ToX motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of trip