Design and synthesis of a new type of mo
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Akiko Saito; Reiko Kuroda
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Article
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1999
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Elsevier Science
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French
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We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-ToX motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of trip