Design considerations for PAMAM dendrimer therapeutics
β Scribed by Goonewardena, Sascha N.; Kratz, Jeremy D.; Zong, Hong; Desai, Ankur M.; Tang, Shengzhuang; Emery, Sarah; Baker, James R.; Huang, Baohua
- Book ID
- 120322489
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 511 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0960-894X
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This communication describes the synthesis and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand. Cell-based experiments demonstrated that a dendrimer conjugated with riboflavin is able to undergo cellular binding and uptake in KB