✦ LIBER ✦
Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery
✍ Scribed by Thommey P. Thomas; Seok Ki Choi; Ming-Hsin Li; Alina Kotlyar; James R. Baker Jr.
- Book ID
- 104004624
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 437 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
This communication describes the synthesis and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand. Cell-based experiments demonstrated that a dendrimer conjugated with riboflavin is able to undergo cellular binding and uptake in KB cells, and when the dendrimer is also conjugated with methotrexate, the riboflavin dendrimer conjugate can potently inhibit cell growth.