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Design, characterization and in vitro evaluation of 5-aminosalicylic acid loaded N-succinyl-chitosan microparticles for colon specific delivery

✍ Scribed by C. Mura; A. Nácher; V. Merino; M. Merino-Sanjuán; M. Manconi; G. Loy; A.M. Fadda; O. Díez-Sales


Book ID
113550591
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
626 KB
Volume
94
Category
Article
ISSN
0927-7765

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The main aim of this research was to develop and evaluate a multiparticulate system of Ac-poly(amidoamine)(PAMAM)(G4)-chitosan (CS) hydrogels exploiting pH-sensitive and specific biodegradability properties for colon-targeted delivery of 5-aminosalicylic acid (5-ASA). All formulations were evaluated